Evidence

Somnotate: A Probabilistic Sleep Stage Classifier for Studying Vigilance StateTransitions.

Brodersen, P. J. N.; Alfonsa, H.; Krone, L. B.; Blanco-Duque, C.; Fisk, A. S.; Flaherty, S. J.;Guillaumin, M. C. C.; Huang, Y.-G.; Kahn, M. C.; McKillop, L. E.; Milinski, L.; Taylor, L.; Thomas,C. W.; Yamagata, T.; Foster, R. G.; Vyazovskiy, V. V.; Akerman, C. J.

PLOS Computational Biology 2024, 20 (1), e1011793.DOI: https://doi.org/10.1371/journal.pcbi.1011793.

Oscillatory-Quality of Sleep Spindles Links Brain State with Sleep Regulation andFunction.

Blanco-Duque, C.; Bond, S. A.; Krone, L. B.; Dufour, J.-P.; Gillen, E. C. P.; Purple, R. J.; Kahn, M.C.; Bannerman, D. M.; Mann, E. O.; Achermann, P.; Olbrich, E.; Vyazovskiy, V. V.

Science Advances 2024, 10 (36), eadn6247.DOI: https://doi.org/10.1126/sciadv.adn6247.

N-methyl-d-aspartate receptors and glycinergic transmission, respectively, mediatemuscle relaxation and immobility of pentobarbital in mice

Akari Mukai, Masahiro Irifune, Yoshitaka Shimizu, Mitsuru Doi, Yuka Kikuchi, SotaroKatayama, Kana Oue, Mitsuhiro Yoshida, Yukio Ago, Yoshiyuki Okada, Norimitsu Morioka,Yoshihiro Nakata, Norio Sakai

Neurosci Lett. 2023 Apr 1:802:137175.DOI: https://doi.org/10.1016/j.neulet.2023.137175

Detection of Neuronal OFF Periods as Low Amplitude Neural Activity Segments.

Harding, C. D.; Guillaumin, M. C. C.; Krone, L. B.; Kahn, M. C.; Blanco-Duque, C.; Mikutta, C.;Vyazovskiy, V. V.

BMC Neurosci 2023, 24 (1), 13.DOI: https://doi.org/10.1186/s12868-023-00780-w.

Neuronal-Spiking-Based Closed-Loop Stimulation during Cortical ON- and OFF-States inFreely Moving Mice.

Kahn, M.; Krone, L. B.; Blanco-Duque, C.; Guillaumin, M. C. C.; Mann, E. O.; Vyazovskiy, V. V.

Journal of Sleep Research 2022, 31 (6), e13603.DOI: https://doi.org/10.1111/jsr.13603.

Psilocin Acutely Alters Sleep-Wake Architecture and Cortical Brain Activity in LaboratoryMice.

Thomas, C. W.; Blanco-Duque, C.; Bréant, B. J.; Goodwin, G. M.; Sharp, T.; Bannerman, D. M.;Vyazovskiy, V. V.

Transl Psychiatry 2022, 12 (1), 77.DOI: https://doi.org/10.1038/s41398-022-01846-9.

Real-Time, Automatic, Open-Source Sleep Stage Classification System Using Single EEGfor Mice.

Tezuka, T.; Kumar, D.; Singh, S.; Koyanagi, I.; Naoi, T.; Sakaguchi, M.

Scientific Reports 11, no. 1 (2021): 11151.doi: https://doi.org/10.1038/s41598-021-90332-1.

The Hypothalamic Link between Arousal and Sleep Homeostasis in Mice.

Yamagata, T.; Kahn, M. C.; Prius-Mengual, J.; Meijer, E.; Šabanović, M.; Guillaumin, M. C. C.;van der Vinne, V.; Huang, Y.-G.; McKillop, L. E.; Jagannath, A.; Peirson, S. N.; Mann, E. O.;Foster, R. G.; Vyazovskiy, V. V.

Proceedings of the National Academy of Sciences 2021, 118(51), e2101580118.DOI: https://doi.org/10.1073/pnas.2101580118.

A role for the cortex in sleep-wake regulation

Lukas B. Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, MartinC. Kahn, Vincent van der Vinne, Laura E. McKillop, Shu K. E. Tam, Stuart N. Peirson, Colin J.Akerman, Anna Hoerder-Suabedissen, Zoltán Molnár & Vladyslav V. Vyazovskiy

Nature Neuroscience volume 24, pages1210-1215 (2021)

Forward Genetics Identifies a Novel Sleep Mutant with Sleep State Inertia and REM SleepDeficits.

Banks, G. T.; Guillaumin, M. C. C.; Heise, I.; Lau, P.; Yin, M.; Bourbia, N.; Aguilar, C.; Bowl, M.R.; Esapa, C.; Brown, L. A.; Hasan, S.; Tagliatti, E.; Nicholson, E.; Bains, R. S.; Wells, S.;Vyazovskiy, V. V.; Volynski, K.; Peirson, S. N.; Nolan, P. M.

Science Advances 2020, 6 (33), eabb3567.DOI: https://doi.org/10.1126/sciadv.abb3567.

Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary forMemory Consolidation.

Kumar, D.; Koyanagi, I.; Carrier-Ruiz, A.; Vergara, P.; Srinivasan, S.; Sugaya, Y.; Kasuya, M.; Yu,T.-S.; Vogt, K. E.; Muratani, M.; Ohnishi, T.; Singh, S.; Teixeira, C. M.; Chérasse, Y.; Naoi, T.;Wang, S.-H.; Nondhalee, P.; Osman, B. A. H.; Kaneko, N.; Sawamoto, K.; Kernie, S. G.; Sakurai,T.; McHugh, T. J.; Kano, M.; Yanagisawa, M.; Sakaguchi, M.

Neuron 107, no. 3 (2020): 552-565.e10.DOI: https://doi.org/10.1016/j.neuron.2020.05.008.

Progressive Changes in Sleep and Its Relations to Amyloid-b Distribution and Learning in Single App Knock-In Mice

Sakura Eri B. Maezono, Mika Kanuka, Chika Tatsuzawa, Miho Morita, Taizo Kawano, Mitsuaki Kashiwagi, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito Takaomi C. Saido, and Yu Hayashi

March/April 2020, 7(2) ENEURO.0093-20.2020 114

Simplified drug efficacy screening system for sleep-disorder drugs using non-human primates

Keita Sakai, Akiyoshi Ishikawa, Yuri Mizuno, Takehiro Maki, Yasuhiro Oda, Eiki Takahashi

Heliyon. 2020 Mar 4;6(3):e03524. DOI: 10.1016/j.heliyon.2020.e03524.

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories

Shuntaro Izawa, Srikanta Chowdhury, Toh Miyazaki, Yasutaka Mukai, Daisuke Ono, Ryo Inoue, Yu Ohmura, Hiroyuki Mizoguchi, Kazuhiro Kimura, Mitsuhiro Yoshioka, Akira Terao, Thomas S. Kilduff, Akihiro Yamanaka

Science 20 Sep 2019: Vol. 365, Issue 6459, pp. 1308-1313 DOI: 10.1126/science.aax9238

Polygraphic Recording Procedure for Measuring Sleep in Mice

Yo Oishi, Yohko Takata, Yujiro Taguchi, Sayaka Kohtoh, Yoshihiro Urade, Michael Lazarus

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Public Sector/Medical Solutions, Kissei Comtech Co., Ltd

Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice

Yu Hayashi, Mitsuaki Kashiwagi, Kosuke Yasuda, Reiko Ando, Mika Kanuka, Kazuya Sakai, Shigeyoshi Itohara

Science 20 Nov 2015: Vol. 350, Issue 6263, pp. 957-961 DOI: 10.1126/science.aad1023

Morning and evening physical exercise differentially regulate the autonomic nervous system during nocturnal sleep in humans

Yujiro Yamanaka, Satoko Hashimoto, Nana N. Takasu, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, and Ken-ichi Honma

Am J Physiol Regul Integr Comp Physiol 309: R1112-R1121, 2015, doi:10.1152/ajpregu.00127.2015.

Differential regulation of circadian melatonin rhythm and sleep-wake cycle by bright lights and nonphotic time cues in humans

Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Natsubori, Shin-ya Nishide, Sato Honma, and Ken-ichi Honma

Am J Physiol Regul Integr Comp Physiol 307: R546-R557, 2014, doi:10.1152/ajpregu.00087.2014.

Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation

Tomomi Tsunematsu, Takafumi Ueno, Sawako Tabuchi, Ayumu Inutsuka, Kenji F. Tanaka, Hidetoshi Hasuwa, Thomas S. Kilduff, Akira Terao, and Akihiro Yamanaka

The Journal of Neuroscience, 14 May 2014, 34(20): 6896-6909;

Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function

Sawako Tabuchi, Tomomi Tsunematsu, Sarah W. Black, Makoto Tominaga, Megumi Maruyama, Kazuyo Takagi, Yasuhiko Minokoshi, Takeshi Sakurai, Thomas S. Kilduff, and Akihiro Yamanaka

The Journal of Neuroscience, 7 May 2014, 34(19): 6495-6509;

Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons

Jing Zhang, Yan Zhu, Guanxia Zhan, Polina Fenik, Lori Panossian, Maxime M. Wang, Shayla Reid, David Lai, James G. Davis, Joseph A. Baur, and Sigrid Veasey

J. Neurosci., Mar 2014; 34: 4418 ? 4431.

Chronic Sleep Restriction Disrupts Sleep Homeostasis and Behavioral Sensitivity to Alcohol by Reducing the Extracellular Accumulation of Adenosine

Jerome Clasadonte, Sally R. McIver, Luke I. Schmitt, Michael M. Halassa, and Philip G. Haydon

J. Neurosci., Jan 2014; 34: 1879 ? 1891.

Dietary Therapy Mitigates Persistent Wake Deficits Caused by Mild Traumatic Brain Injury

Miranda M. Lim, Jaclynn Elkind, Guoxiang Xiong, Ray Galante, Jingxu Zhu, Lin Zhang, Jie Lian, Julianna Rodin, Nicholas N. Kuzma, Allan I. Pack, and Akiva S. Cohen

Science Translational Medicine, Dec 2013; 5: 215ra173.

Optogenetic Stimulation of MCH Neurons Increases Sleep

Roda Rani Konadhode, Dheeraj Pelluru, Carlos Blanco-Centurion, Andrew Zayachkivsky, Meng Liu, Thomas Uhde, W. Bailey Glen, Jr, Anthony N. van den Pol, Patrick J. Mulholland, and Priyattam J. Shiromani

J. Neurosci., Jun 2013; 33: 10257 ? 10263.

Role of the Medial Prefrontal Cortex in Cataplexy

Yo Oishi, Rhiannan H. Williams, Lindsay Agostinelli, Elda Arrigoni, Patrick M. Fuller, Takatoshi Mochizuki, Clifford B. Saper, and Thomas E. Scammell

J. Neurosci., Jun 2013; 33: 9743 ? 9751.

Auditory Responses and Stimulus-Specific Adaptation in Rat Auditory Cortex are Preserved Across NREM and REM Sleep

Yuval Nir, Vladyslav V. Vyazovskiy, Chiara Cirelli, Matthew I. Banks, and Giulio Tononi

Cereb Cortex, Dec 2013; 10.1093/cercor/bht328

Extracellular Signal-Regulated Kinase (ERK) Activity During Sleep Consolidates Cortical Plasticity In Vivo

Michelle C. Dumoulin, Sara J. Aton, Adam J. Watson, Leslie Renouard, Tammi Coleman, and Marcos G. Frank

Cereb Cortex, Sep 2013; 10.1093/cercor/bht250.

Amygdala Lesions Reduce Cataplexy in Orexin Knock-Out Mice

Christian R. Burgess, Yo Oishi, Takatoshi Mochizuki, John H. Peever, and Thomas E. Scammell

J. Neurosci., Jun 2013; 33: 9734 ? 9742

Sleep spindles are generated in the absence of T-type calcium channel-mediated low-threshold burst firing of thalamocortical neurons

Jungryun Lee, Kiyeong Song, Kyoobin Lee, Joohyeon Hong, Hyojung Lee, Sangmi Chae, Eunji Cheong, and Hee-Sup Shin

PNAS, Dec 2013; 110: 20266 ? 20271.

Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy

Jerome Clasadonte, Jinghui Dong, Dustin J. Hines, and Philip G. Haydon

PNAS, Oct 2013; 110: 17540 ? 17545

Effects of Sleep and Wake on Oligodendrocytes and Their Precursors

Michele Bellesi, Martha Pfister-Genskow, Stephanie Maret, Sunduz Keles, Giulio Tononi, and Chiara Cirelli

J. Neurosci., Sep 2013; 33: 14288 ? 14300.

Sleep Stage Assessment Using Power Spectral Indices of Heart Rate Variability With a Simple Algorithm: Limitations Clarified From Preliminary Study

Keiko Tanida, Masashi Shibata, and Margaret M. Heitkemper

Biol Res Nurs, Jul 2013; 15: 264 ? 272.

Progressive sleep and electroencephalogram changes in mice carrying the Huntingtonfs disease mutation

Sandor Kantor, Lajos Szabo, Janos Varga, Marc Cuesta, and A. Jennifer Morton

Brain, Jul 2013; 136: 2147 ? 2158.

Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation

Jasbir Dalal, Jee Hoon Roh, Susan E. Maloney, Afua Akuffo, Samir Shah, Han Yuan, Brie Wamsley, Wendell B. Jones, Cristina de Guzman Strong, Paul A. Gray, David M. Holtzman, Nathaniel Heintz, and Joseph D. Dougherty

Genes and Dev., Mar 2013; 27: 565 ? 578.

Feeding-elicited cataplexy in orexin knockout mice.

E. L. CLARK,a C. R. BAUMANN,a,b G. CANO,a T. E. SCAMMELLa AND T. MOCHIZUKI

Neuroscience 161 (2009) 970.977

Effects of some antipsychotics and a benzodiazepine hypnotic on the sleep-wake pattern in an animal model of schizophrenia.

Ishida,T,Obara Y, Kamei C

J Pharmacol Sci. 2009 Sep;111(1):44-52. Epub 2009 Aug 29

Neural circuitry of stress-induced insomnia in rats.

Georgina Cano, Takatoshi Mochizuki, and Clifford B. Saper

The Journal of Neuroscience, October 1, 2008 . 28(40):10167.10184 . 10167

Studies on somnolence in the daytime caused by drugs used for neuropathic pain.

Takeda Y, Ishida T, Tsutsui R, Toide K, Tanimoto-Mori S, Watanabe S, Kanai Y, Kamei C.

J Pharmacol Sci. 2008 Jul;107(3):246-50. Epub 2008 Jun 28.

Algorithm for sleep scoring in experimental animals based on fast Fourier transform power spectrum analysis of the electroencephalogram

Sayaka KOHTOH, Yujiro TAGUCHI, Naomi MATSUMOTO, Masashi WADA, Zhi-Li HUANG and Yoshihiro URADE

Sleep and Biological Rhythms Volume 6, Issue 3, pages 163-171, July 2008

Effects of Ibotenate and 192IgG-Saporin Lesions of the Nucleus Basalis Magnocellularis/Substantia Innominate on Spontaneous Sleep and Wake States and on Recovery Sleep after Sleep Deprivation in Rats

SembaSatvinder Kaur, Adrienne Junek, Michelle A. Black, and Kazue Semba

J. Neurosci., Jan 2008; 28: 491-504

Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

Pascal Bonaventure, Lisa Kelly, Leah Aluisio, Jonathan Shelton, Brian Lord, Ruggero Galici, Kirsten Miller, John Atack, Timothy W. Lovenberg, and Christine Dugovic

J. Pharmacol. Exp. Ther., May 2007; 321: 690 ? 698.

Altered Circadian and Homeostatic Sleep Regulation in Prokineticin 2-Deficient Mice

Wang-Ping Hu,PhD1; Jia-Da Li, PhD1; Chengkang Zhang, PhD1; Lisa Boehmer, PhD2; Jerome M. Siegel, PhD2; Qun-Yong Zhou, PhD1

SLEEP, Vol. 30, No. 3, 2007

Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism

Qing-Ping Chu, Li-En Wang, Xiang-Yu Cui, Hong-Zheng Fu, Zhi-Bin Lin, Shu-Qian Lin, Yong-He Zhang

Pharmacology Biochemistry and Behavior, Volume 86, Issue 4, April 2007, Pages 693-698

Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy

Shengwen Zhang, Jamie M. Zeitzer, Takeshi Sakurai, Seiji Nishino, and Emmanuel Mignot

J. Physiol., Jun 2007; 581: 649 ? 663.

Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability

Aihua Li and Eugene Nattie

J. Physiol., Jan 2006; 570: 385 ? 396.

Altered sleep.wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice

Zhi-Li Huang, Takatoshi Mochizuki, Wei-Min Qu, Zong-Yuan Hong, Takeshi Watanabe, Yoshihiro Urade, and Osamu Hayaishi

PNAS, Mar 2006; 103: 4687 ? 4692.

Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep

Wei-Min Qu, Zhi-Li Huang, Xin-Hong Xu, Kosuke Aritake, Naomi Eguchi, Fumio Nambu, Shu Narumiya, Yoshihiro Urade, and Osamu Hayaishi

PNAS, Nov 2006; 103: 17949 ? 17954.

Attenuated Circadian Rhythms in Mice Lacking the Prokineticin 2 Gene

Jia-Da Li, Wang-Ping Hu, Lisa Boehmer, Michelle Y. Cheng, Alex G. Lee, Alexander Jilek, Jerome M. Siegel, and Qun-Yong Zhou

J. Neurosci., Nov 2006; 26: 11615 ? 11623.

Excitatory and Inhibitory Actions of Isoflurane in Cholinergic Ascending Arousal System of the Rat

Hailong Dong, M.D., Ph.D., Satoru Fukuda, M.D., Ph.D., Tetsuro Isada, M.D., Hirotake Eguchi, M.D., Hisato Suzuki, M.D.

Anesthesiology 2005; 103: A155

Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rat s

Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.

Psychopharmacology (Berl) 2005 Feb 8

Effects of Valerian Extract on the Sleep-wake Cycle in Sleep-disturbed Rats

Kazuaki Shinomiya, Katsuyuki Fujimura, Yonsu Kim, and Chiaki Kamei

Acta Med Okayama. 2005 Jun;59(3):89-92.

An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats

Zong-Yuan Hong, Zhi-Li Huang, Wei-Min Qu, Naomi Eguchi, Yoshihiro Urade and Osamu Hayaishi

Journal of Neurochemistry Volume 92 Issue 6 Page 1542 ? March 2005 doi:10.1111/j.1471-4159.2004.02991.x

Despite Similar Anxiolytic Potential, the 5-Hydroxytryptamine 2C Receptor Antagonist SB-242084 [6-Chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl Carbamoyl] Indoline] and Chlordiazepoxide Produced Differential Effects on Electroencephalogram Power Spectra

Sandor Kantor, Rita Jakus, Eszter Molnar, Norbert Gyongyosi, Attila Toth, Laszlo Detari, and Gyorgy Bagdy

Journal of Pharmacology And Experimental Therapeutics Fast Forward First published on August 5, 2005; DOI: 10.1124/jpet.105.086413

COMPARATIVE EFFECT OF MELATONIN AND ZOLPIDEM ON SLEEPUSING RADIOTELEMETRY IN RATS

Simon P Fisher, Kathryn Davidson, and David Sugden

European Pineal and Biological Rhythms Society 2005Poster presentation

Adenosine A2A, but not A1,receptors mediate the arousal effect of caffeine

Zhi-Li Huang, Wei-Min Qu, Naomi Eguchi, Jiang-Fan Chen, Michael A Schwarzschild, Berti B Fredholm, Yoshihiro Urade & Osamu Hayaishi

Nature Neuroscience, Published online: 19 June2005; doi: 10, 1038/nn1491

Thalamic Cav3.1 T-type Ca2_ channel plays a crucial role in stabilizing sleep

Matthew P. Anderson, Takatoshi Mochizuki, Jinghui Xie, Walter Fischler, Jules P.Manger, Edmund M. Talley, Thomas E. Scammell, and Susumu Tonegawa

www.pnas.org/cgi/doi/10.1073/pnas.0409644102,December, 2004

Characterization Of The SleepPatterns Of Fatty Acid Amide Hydrolase Knockout Mice

Huitron-Resendiz S, Gallegos RA, Wills DN, Zhukov VI, CravattBF, Henriksen SJ

Journal Sleep 2003Abstracts

AUTOMATIC VIGILANCE STATE CLASSIFICATION OF RATS AND MICEUSING COMMERCIAL SLEEP ANALYSIS SOFTWARE

Gallegos RA, Huitron-ResendizS, Sanchez-Alavez M, CriadoJR,Wills DN, Henriksen SJ

Journal Sleep 2002Abstracts

SLEEP/WAKE PATTERNS IN MICE LACKING FATTY ACID AMIDEHYDROLASE

S.Huitron-Resendiz; M.Sanchez-Alavez; D.N.Wills; B.F.Cravatt; S.J.Henriksen

Soceity for Neuroscience 2004 Poster presentation

SLEEP/WAKE BEHAVIOR IN MCH OVEREXPRESSING MICE

Cronin SJ, Mochizuki T, Papadopoulou M, TromblyD, Maratos-Flier E, Scammell TE

Journal Sleep 2002Abstracts

Lack of delta waves and sleep disturbances duringnon-rapid eye movement sleep in mice lacking 1G-subunit of T-type calciumchannels

Jungryun Lee, Daesoo Kim, and Hee-Sup Shin

PNAS | December 28, 2004 | vol. 101 | no. 52 |18195-18199

Sleep Deprivation and Cellular Responses to OxidativeStress

Anupama Gopalakrishnan, PhD; LiLi Ji, PhD; Chiara Cirelli MD, PhD

Sleep. 2004 Feb 1;27(1):27-35.

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin NeuronsInduces Narcolepsy–Cataplexy in the Rat

Carsten T. Beuckmann, Christopher M. Sinton, S. Clay Williams, JamesA. Richardson, Robert E. Hammer, Takeshi Sakurai, and Masashi Yanagisawa

The Journal of Neuroscience, May 5, 2004,24(18):4469-4477

Despite Similar AnxiolyticPotential, the 5-Hydroxytryptamine 2C Receptor Antagonist SB-242084 [6-Chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-ylCarbamoyl] Indoline] and Chlordiazepoxide Produced Differential Effects onElectroencephalogram Power Spectra

Sandor Kantor,Rita Jakus, Eszter Molnar,Norbert Gyongyosi, Attila Toth,Laszlo Detari, and Gyorgy Bagdy

Journal of Pharmacology AndExperimental Therapeutics Fast Forward First published on August 5, 2005; DOI:10.1124/jpet.105.086413

Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505

Kantor S, Jakus R, Balogh B, Benko A, Bagdy G.

Br J Pharmacol. 2004 Aug;142(8):1332-42. Epub 2004 Jul 20.

Effects of asingle dose of 3,4-methylenedioxymethamphetamine oncircadian patterns, motor activity and sleep in drug-naive rats and ratspreviously exposed to MDMA

Brigitta Balogh, Eszter Molnar, Rita Jakus, Linda Quate, Henry J. Olverman, Paul A. T. Kelly, SandorKantor and Gyorgy Bagdy

Psychopharmacology (Berl). 2004 May;173(3-4):296-309. Epub 2004 Apr 9

Accuracy evaluation of sleep-wake stage analysis with SleepSign Ver2.0

Yujiro TAGUCHI, Shima HANDO, Mie SAKATA, Naomi EGUCHI and YoshihiroURADE

Sleep andBiological Rhythms Volume 2 Issues1PageS58 - May 2004 doi:10.1111/j.1479-8425.2004.00117.x

Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats

MinChua,Zhi-Li Huanga, Wei-Min Qu,Naomi Eguchi, Ming-Hui Yao, Yoshihiro Urade

NeuroscienceResearch 49 (2004) 417-420

An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats

Zong-Yuan Hong, Zhi-Li Huang, Wei-Min Qu, Naomi Eguchi, Yoshihiro Urade and OsamuHayaishi

Journal ofNeurochemistry Volume 92 Issue 6 Page 1542 - March 2005 doi:10.1111/j.1471-4159.2004.02991.x

Minireview:Sleep regulation in adenosine A2A receptor-deficient mice

Yoshihiro Urade, Naomi Eguchi, Wei-Min Qu, Mie Sakata, Zhi-Li Huang,Jiang-Fan Chen, Michael A. Schwarzschild, J. Stephen Fink, and Osamu Hayaishi

Neurology,Vol. 61, Issue 90116, S -96, December 9, 2003

Dominantlocalization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep

Akira Mizoguchi, Naomi Eguchi, KazushiKimura, Yoshimoto Kiyohara, Wei-Min Qu, Zhi-Li Huang, Takatoshi Mochizuki, MichaelLazarus,Takuya Kobayashi, Takeshi Kaneko, Shuh Narumiya, Yoshihiro Urade, andOsamu Hayaishi

Proc Natl Acad SciU S A. 2001 Sep 25;98(20):11674-9. Epub2001 Sep 18.

Prostaglandin E2 Activates the Histaminergic System via the EP4 Receptor to Induce Wakefulness in Rats

Zhi-Li Huang, Yo Sato, Takatoshi Mochizuki,Tetsuya Okada, Wei-Min Qu, Atsushi Yamatodani, Yoshihiro Urade, andOsamu Hayaishi

The Journal of Neuroscience,July 9,2003, 23(14):5975-5983

Arousal effect of orexin A depends on activation of the histaminergic system

Zhi-Li Huang,Wei-Min Qu, Wei-Dong Li, TakatoshiMochizuki, Naomi Eguchi, Takeshi Watanabe, Yoshihiro Urade, and Osamu Hayaishi

PNAS |August 14, 2001 | vol. 98 | no. 17 | 9965-9970

Effects of Valerian Extract on the Sleep-wake Cycle in Sleep-disturbed Rats

Kazuaki Shinomiya, Katsuyuki Fujimura, Yonsu Kim, and Chiaki Kamei

Acta Med Okayama. 2005 Jun;59(3):89-92.

Effects of three hypnotics on the sleep-wakefulness cycle in sleep-disturbed rats

Shinomiya K, Shigemoto Y, Omichi J, Utsu Y, Mio M, Kamei C.

Psychopharmacology (Berl). 2004 Apr;173(1-2):203-9. Epub 2004 Jan 14.

Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rat s

Shinomiya K, Inoue T,Utsu Y, Tokunaga S, MasuokaT, Ohmori A, Kamei C.

Psychopharmacology(Berl) 2005 Feb 8

Excitatory and Inhibitory Actions of Isoflurane in Cholinergic Ascending Arousal System of the Rat

Hai-Long Dong, M.D.,Ph.D., Satoru Fukuda, M.D., Ph.D., Tetsuro Isada, M.D., Hirotake Eguchi, M.D., Hisato Suzuki, M.D.

Anesthesiology2005; 103: A155

AttenuatedCircadian Rhythms in Mice Lacking the Prokineticin 2Gene

Jia-Da Li,Wang-Ping Hu, Lisa Boehmer,Michelle Y. Cheng, Alex G. Lee, Alexander Jilek,Jerome M. Siegel, and Qun-Yong Zhou

J. Neurosci., Nov 2006; 26: 11615 - 11623.

Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy

Shengwen Zhang, Jamie M. Zeitzer, Takeshi Sakurai, Seiji Nishino, andEmmanuel Mignot

J. Physiol., Jun 2007; 581: 649 - 663.

Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep

Wei-Min Qu, Zhi-Li Huang, Xin-Hong Xu, KosukeAritake, Naomi Eguchi,Fumio Nambu, Shu Narumiya, Yoshihiro Urade, andOsamu Hayaishi

PNAS, Nov2006; 103: 17949 - 17954.

Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice

Zhi-Li Huang, Takatoshi Mochizuki, Wei-Min Qu, Zong-Yuan Hong, Takeshi Watanabe, Yoshihiro Urade, and Osamu Hayaishi

PNAS, Mar 2006; 103: 4687 - 4692.

Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability

Aihua Li andEugene Nattie

J. Physiol., Jan 2006; 570: 385 - 396.

SelectiveBlockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission,Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Inducedby Citalopram in Rodents

PascalBonaventure, Lisa Kelly, Leah Aluisio, JonathanShelton, Brian Lord, Ruggero Galici,Kirsten Miller, John Atack, Timothy W. Lovenberg, and Christine Dugovic

J. Pharmacol. Exp. Ther., May 2007;321: 690 - 698.

Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain

Yasuhiro Takeda, Takayuki Ishida, Ryuki Tsutsui, Katsuo Toide, Sachi Tanimoto-Mori, Shuzo Watanabe, Yoshihito Kanai and Chiaki Kamei

Journal of Pharmacological Sciences Vol. 107 (2008) , No. 3 pp.246-250

Algorithm for sleep scoring in experimental animals based on fast Fourier transform power spectrum analysis of the electroencephalogram

Sayaka KOHTOH, Yujiro TAGUCHI, Naomi MATSUMOTO, Masashi WADA, Zhi-Li HUANG, Yoshihiro URADE

Sleep and Biological Rhythms Volume 6, Issue 3, pages 163?171, July 2008

Drug delivery through a chronically implanted stomach catheter improves efficiency of evaluating wake-promoting components

Wei-Min Qua, Zhi-Li Huanga, b, Naomi Matsumotoa, Xin-Hong Xua, b and Yoshihiro Urade

Journal of Neuroscience Methods Volume 175, Issue 1, 30 October 2008, Pages 58-63

Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat

Simon P. Fisher, David Sugden

Neuroscience Letters Volume 457, Issue 2, 26 June 2009, Pages 93-96

Studies on wakefulness-promoting effect of memantine in rats

Takayuki Ishida, Yoshihito Obara, Chiaki Kamei

Behavioural Brain Research Volume 206, Issue 2, 20 January 2010, Pages 274-278

EEG, activity and sleep architecture in a transgenic APPSWE/PSEN1A246E Alzheimer mouse.

Amar Jyoti, Andrea Plano, Gernot Riedel & Bettina Platt.

Journal of Alzheimer's Disease (2010 - 22(3):873-87)

Abnormal cognition, sleep, EEG and brain metabolism in a knock-in Alzheimer mouse, PLB1

B. Platt, B. Drever, D. Koss, S. Stoppelkamp1, A. Jyoti, A. Plano, A. Utan, G. Merrick, D. Ryan, V. Melis, H. Wan, M. Mingarelli, E. Porcu, L. Scrocchi, A. Welch, G. Riedel.

(2011 - PLoS ONE 6(11): e27068. doi:10.1371/journal.pone.0027068)

A pilot study into the effects of the CB1 cannabinoid receptor agonist, WIN55, 212-2 or the antagonist/inverse agonist AM251 on sleep in rats.

A. Goonawardena, A.Plano, L. Robinson, B.Platt, R. Hampson, G.Riedel.

(2011 - Sleep Disorders - accepted)

Protein Synthesis during Sleep Consolidates Cortical Plasticity In Vivo.

Seibt,J.; Dumoulin, M.C.; Aton, S.J.; Coleman, T.; Watson, A.; Naidoo, N.; Frank, M.G.

(2012 - Current Biology 22, 676?682, April 24, 2012 Elsevier Ltd (Report))

Effect of nicotine withdrawal on sleep quantity and quality in rats.

Mathews, H.L.; Malin, D.H.; Feiler, P.; Thompson, L.; Bautisa, J.; Negrete, A. Goyarzu, P.; Ward, C.P.

(2012 - Poster at SFN 2012, October 2012)